Induction of Apoptosis in Cancer Cells at Low Silver Nanoparticle Concentrations using Chitosan Nanocarrier

In this clinical study, published in the journal ACS Applied Material & Interfaces in January 2011, researchers used a chitosan-based carrier to deliver silver nanoparticles to human colon cancer cells.

According to the study authors, “Cell viability assay demonstrated that the concentration of Ag NPs required to reduce the viability of HT 29 cells by 50% was 0.33 µg mL-1, much less than in previously reported data.” In other words, the researchers found that it only took a concentration of 3.3 ppm silver nanoparticles to reduce cancer cells by 50% in vitro.

The researchers further stated, “The increased production of intracellular ROS due to Ag-CS NCs treatment indicated that the oxidative stress could augment the induction of apoptosis in HT 29 cells in addition to classical caspase signaling pathway. The use of significantly low concentration of Ag NPs impregnated in chitosan nanocarrier is a much superior approach in comparison to the use of free Ag NPs in cancer therapy.” In other words, the silver nanoparticles induced reactive oxygen species inside the cancer cells, resulting in an activation of the cellular signaling pathway that controls apopotosis (cellular suicide), and thereby triggering the cancer cells to self-destruct.

Click the image above to learn more about the Micro-Particle Colloidal Silver Generator that allows you to make high-quality colloidal silver for less than 36 cents a quart, and is so easy to use, even my 88 year old mom uses one!


P.O. Box 84910
Phoenix, AZ 85071

Phone Orders/Customer Service: 1-888-528-0559 (M-F, 8am to 4pm AZ time)
FAX Orders: (602) 943-2363 (24 hours a day)
Tech Support: (760) 253-2988 (M-F 9am to 5pm CA time)

Email Sales/Customer Service: sales@thesilveredge.com
Email Tech Support: techsupport@thesilveredge.com

Copyright . No reproduction without the expressed written permission of The Silver Edge.

[IMPORTANT NOTE AND DISCLAIMER: We are not doctors. We are distributors of electronic appliances and nutritional supplements. Therefore we cannot and do not offer medical advice. Please do not call with medical questions. If you have a medical problem, please see your licensed physician. Self-treatment is not recommended. The FDA has not evaluated the information contained on this web site. Products distributed by The Silver Edge are not intended to diagnose, treat, cure or prevent any disease. Testimonials are the subjective experiences of our customers and are not intended to be construed as being prescriptive in nature, nor a guarantee that the usage methods described are safe, effective or reliable, nor a guarantee that your results will be the same; individual results may vary. Additionally, the contents of this web site are strictly for information purposes only, and should not in any way be construed as providing or attempting to provide medical advice. Information on this web site is derived from sources deemed to be accurate and reliable, but no guarantee, express or implied, can be made regarding the accuracy or reliability of same. Therefore readers are encouraged to verify for themselves and to their own satisfaction the accuracy and reliability of all reports, recommendations, conclusions, comments, and opinions. The Silver Edge does not make any claims or promises as to health benefits accruing from the use of any product. There is plenty of publicly available independent documentation -- both pro and con -- regarding the uses and efficacy of colloidal silver and its long history in health and medicine. For a comprehensive overview, you may want to obtain a copy of The Ultimate Colloidal Silver Manual (547 pages, from Life & Health Research Group, LLC, 1-888-846-9029). Or see the link above to "Some Interesting Sources of Information on Colloidal Silver." Colloidal silver generators are electronic appliances designed to produce high-quality silver colloid. They are not medical devices. The Silver Edge specifically disclaims responsibility or liability for any loss or hardship that may be incurred by the reader as a result of the application of any information included on this web site, or as a result of the use or misuse of any electronic product or nutritional supplement. You are solely responsible for your health and nutrition choices. Anyone with additional information on colloidal silver is encouraged to write to The Silver Edge at the address directly below, so that it can be shared with others who may be interested.]