Cytotoxicity and ROS Production of Manufactured Silver Nanoparticles of Different Sizes in Hepatoma and Leukemia Cells
In this clinical study, published in the Journal of Applied Toxicology in November 2013, the researchers set out to investigate how AgNPs of different sizes interact with two different tumoral human cell lines, i.e., hepatoma [HepG2] and leukemia [HL-60], i.e., liver cancer cells and blood cancer cells.
Using silver nanoparticles of 4.7 nm and 42 nm in size, respectively, the researchers discovered that the smaller silver nanoparticles had the most cytotoxic effect against the cancer cells. What’s more, the researchers found that the liver cancer cells were more sensitive to the silver nanoparticles than the leukemia cells, although the silver proved to be cytotoxic to both types of cancer cells.
