Colloidal Silver Nanoparticles Improve Anti-leukemic Drug Efficacy via Amplification of Oxidative Stress
In this clinical study, published in the journal Colloids and surfaces. B, Biointerfaces in February 2015, researchers demonstrated that when silver nanoparticles are added to anti-leukemia drugs, the silver improved the effectiveness of the drugs by amplifying oxidative stress on the leukemic cancer cells.
The study authors wrote, “It has been known that silver nanoparticles (AgNPs) display anti-leukemic activity via ROS overproduction. Hence, we hypothesized that AgNPs could improve therapeutic efficacy of ROS-generating agents against leukemia cells.” The study authors concluded, “Taken together, these results reveal that AgNPs combined with ROS-generating drugs could potentially enhance therapeutic efficacy against leukemia cells, thereby providing a novel strategy for AgNPs in leukemia therapy.”
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