Silver Nanoparticles Kill Colon Cancer Cells: 12 Studies


Silver Nanoparticles Kill Colon Cancer Cells: 12 Studies

By Steve Barwick, author, The Ultimate Colloidal Silver Manual

According to the CDC, “Of cancers that affect both men and women, colorectal cancer is the second leading cause of cancer-related deaths in the United States. It is the third most common cancer in men and in women.”

Indeed, there are as many as 135,430 new cases of colon and rectal cancers in the U.S. each year, resulting in 50,260 deaths. One in every 20 people will be diagnosed with colorectal cancer (colon or rectal cancer).

New Studies Demonstrate
Silver Kills Colon Cancer Cells

Thankfully, there have been a growing number of in vitro (i.e., “test tube”) clinical studies over the last 10 years using various forms of antimicrobial silver against colon cancer cells, each of which have demonstrated silver’s effectiveness against the cancer cells. We’ll take a quick look at twelve of these studies, below.

For example, the according to a 2012 article in the UK Daily Mail, titled “Silver Bullet for Cancer: Metal Can Kill Some Tumours Better than Chemotherapy with Fewer Side Effects,” we find the following fascinating information:

Researchers from the University of Leeds conducted lab tests which exposed breast and colon cancer cells to various silver-based chemicals over a six day period.

Results, published in journal Dalton Transactions, showed that these silver-compounds were ‘as effective as Cisplatin’ at killing cancer with potentially fewer side effects.

While the team are still unsure about how exactly silver battles cancer, they think its effectiveness may be caused by the structure surrounding silver atoms, known as its ligand. 

They think this may help release the silver ion into cells when it enters the body, killing any cancer.

Study author Dr Charlotte Willans plans to spend the next year looking closely at what effect silver has on both cancerous and healthy cells, and whether it could be a safe and effective new anti-cancer drug.”

So in the above-mentioned study, which was titled “Enhanced Cytotoxicity Of Silver Complexes Bearing Bidentate N-Heterocyclic Carbene Ligands” the silver-based chemicals proved to be as effective against breast cancer cells and colon cancer cells as the popular anti-cancer chemotherapy drug, Cisplantin, but with fewer side effects.

According to Dr. Willans, who authored the study, “This could lead to a cheaper, less toxic alternative to current treatments for cancer.”

A Second Interesting Clinical Study

According to a clinical study published in February 2011 and titled “Induction Of Apoptosis In Cancer Cells At Low Silver Nanoparticle Concentrations Using Chitosan Nanocarrier,” clinical researchers coated silver nanoparticles in a chitosan-based carrier and then used them on a colon cancer cell line.

The result? “Using a considerably lower concentration of silver nanoparticles, they efficiently induced apoptosis through ROS generation in human colon cancer cells (HT 29).”

In other words, the researchers created a novel silver compound made out of chitosan (carbohydrate sugar molecules) and silver nanoparticles. (Keep in mind that researchers create these “novel” silver compounds so they can afterwards patent the process and potentially sell the end-product to Big Pharma as a “drug.”)

They then tested these silver nanoparticles on the HT 29 line of human colon cancer cells. The result was that very small concentrations of the nanosilver were needed to cause the colon cancer cells to die.

Upon contact with the colon cancer cells, the silver nanoparticles induced ROS (i.e., “reactive oxygen species,” which is similar in effect of hydrogen peroxide) causing the unhealthy cancer cells to begin dying off.

Most exiting was the fact that a concentration of less than 1 ppm (actually, closer to 1 ppb — a nearly insignificant amount) of the silver nanoparticles was all it took to reduce the colon cancer cell growth by 50% (in a test tube), which the study authors say was “much less than in previously reported data.”

A Third Clinical Study

But those aren’t the only clinical studies demonstrating silver to be effective against colon cancer cells.

Indeed, in a study titled “Anticancer Activity of Biosynthesized Silver Nanoparticles using Murraya koenigii Leaf Extract against HT-29 Colon Cancer Cell Line,” silver nanoparticles that were manufactured using curry leaf extract (another “novel” method of creating patentable silver nanoparticles) and then exposed to an HT-29 colon cancer cell line.

The study, published in the Journal of Cancer Science & Therapy in 2018, concluded as follows:

The anticancer potential of the nanoparticles was evaluated using MTT assay on HT-29 colon cancer cell line.

Ag NPs showed potent cytotoxic activity against the human colorectal adenocarcinoma (HT-29) cell line at higher concentrations [i.e., 82.39, 83.57 and 78.78 ppm].

This study insights the M. koenigii synthesized silver NP’s could be an effective applicability drug candidate for colon cancer.”

In other words, silver nanoparticle concentrations ranging from 78 ppm to 83 ppm demonstrated “potent cytotoxic activity” against the cancer cell line. And the researchers characterized the silver nanoparticles as potential candidates for colon cancer treatment.

A Fourth Clinical Study

In another study, published in the journal Nanomedicine in March 2013 and titled “Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53,” researchers wrote:

“The authors have systematically investigated the anticancer potentiality of silver-based nanoparticles (AgNPs) and the mechanism underlying their biological activity in human colon cancer cells.

…Starch-capped AgNPs were synthesized, characterized and their biological activity evaluated through multiple biochemical assays. Results: AgNPs decreased the growth and viability of HCT116 colon cancer cells. AgNP exposure increased apoptosis…

…In the present report, we have shown for the first time that AgNps exhibit anticancer activity in colon cancer cells and determined the mechanism of action. This study has systematically established the anticancer activity of AgNPs against colon cancer cells.

… Conclusion: The data provide strong evidence that AgNPs should be studied further as potential novel anticancer agents to treat colon cancer with an interesting mechanism of action.

…AgNPs are bona fide anticancer agents that act in a p53-dependent manner.”

Wow. Like the other studies, this one too found that silver nanoparticles, upon contact with the colon cancer cells, caused them to commit cellular suicide (i.e., apoptosis).

You may have noticed in the quote above that the researchers used “starch-capped” silver nanoparticles — once again, a way of creating a “novel” silver compound that can later be patented and utilized as a “drug.”

A Fifth Clinical Study

In another study, this one titled “Exposure to Silver Nanoparticles Induces Size- and Dose-dependent Oxidative Stress and Cytotoxicity in Human Colon Carcinoma Cells” and published in July 2014 in the journal Toxicology In Vitro, clinical researchers once again set out to evaluate the effects of silver nanoparticles against human colon cancer cells.

The researchers tested “the size-dependent effects of AgNPs by treating the human LoVo cell line, an intestinal epithelium model, with spherical AgNPs of well-defined sizes (10, 20, 40, 60 and 100nm).”

In other words, they decided to test silver particles of five different particle sizes against colon cancer cells.

Results: The smaller the silver particles were, the more effectively they penetrated the cancer cells, resulting in the “stimulation of a signaling cascade that generated ROS and inflammatory markers, leading to mitochondrial dysfunction and subsequently inducing apoptosis.”

In other words, the smallest silver particles caused the colon cancer cells to self-destruct, whereas the largest of the silver particles (100 nm) could not even penetrate the cancer cells. This once again proves the old maxim that when it comes to silver, smaller silver particles truly work better.

A Sixth Clinical Study

In another clinical study, titled “Comparative Cytotoxicity Of Nanosilver In Human Liver Hepg2 And Colon Caco2 Cells In Culture,” and published in the Journal of Applied Technology in February 2014, the researchers treated human liver HepG2 cells (i.e., liver cancer cells) and human colon Caco2 cells (i.e., colorectal colon cancer cells) with silver nanoparticles with an average size of 20.4 nm in order to evaluate their toxicity to the cells.

The researchers found significant toxicity to both cancer cell lines, but at different concentrations, with the colorectal (colon) cancer cells requiring a concentration of silver nanoparticles 10 times higher than the liver cancer cells.

In this case, the researchers were doing something I’ve long railed against, i.e., rather than using healthy human cell lines to test silver’s toxicity to human cells, they were using cancer cell lines.

This is problematic, because you can’t extrapolate the potential toxicity of silver to healthy human cells by testing them on cancerous cells. That’s because silver has an affinity for cancer cells, i.e., it seems to target them and cause them to commit cellular suicide (apoptosis), while leaving surrounding healthy human cells without harm.

To their credit, the authors of the above study more or less admitted this, stating:

The HepG2 and Caco2 cells used this study appear to be targets for silver nanoparticles. 

The results of this study suggest that the differences in the mechanisms of toxicity induced by nanosilver may be largely as a consequence of the type of cells used. 

This differential rather than universal response of different cell types exposed to nanoparticles may play an important role in the mechanism of their toxicity.”

In other words, cancer cells turn out to be far more sensitive to the cytotoxic effects of silver nanoparticles, with some types of cancer cells being more sensitive to others.

The researchers concluded: “The mitochondrial injury in HepG2 cells was significant in the concentration range of 1 to 20 μgml(-1), but in Caco2 cells it was significant at a higher concentration range of 10 to 20 μgml(-1).”

In short, the silver nanoparticles were demonstrated to be toxic against the liver cancer cells at concentrations between 1ppb to 2 ppm, whereas they were toxic against the colon cancer cells at concentrations between 1 to 2 ppm.

Note the exceedingly small concentrations, which would be very similar to conditions in the human body after ingesting a higher concentration. The human body would dilute the silver to a similar or lower concentration depending upon the individual’s body volume, mass (weight), and the quantity of blood and interstitial fluids present.

A Seventh Clinical Study

In this clinical study, titled “Novel Trend in Colon Cancer Therapy Using Silver Nanoparticles Synthesized by Honey Bee” and published in February 2015 in the Journal of Nanomedicine & Nanotechnology, researches synthesized silver nanoparticles using an extract from dead honey bees (talk about creating a “novel” way of making silver nanoparticles, this one has to take the cake!).

“In the current study, the novelty in the biosynthesis of silver nanoparticles (AgNPs) using honey bee extract has been explained.

This study was also aiming at investigating the anti-colon cancer activities of the biogenic AgNPs along with its capping biomolecules in vitro. 

…  it was found that both AgNPs and its capping biomolecules have anti-proliferative effects with a priority to the naked AgNPs.

In other words, the researchers found that both the “biomolecules” (i.e., the honey bee extract) and the silver nanoparticles stopped the colon cancer cells from growing (i.e., “anti-proliferative effects”). But the silver nanoparticles had the most profound anti-cancer effects.

The researchers concluded their study by stating:

This study reports that 12-18 nm sized biogenic AgNPs have been successfully synthesized using honey bee extract as a novel reducing agent.

Both the obtained AgNPs and their capping biomolecules showed anti-colon cancer activities at both cellular and molecular levels comparing with 5 FU.

In conclusion, the single-step and ecofriendly synthesized AgNPs could be a promising agent in colon cancer therapy or drug delivery.”

So once again we see researchers working to create “novel” forms of silver nanoparticles — in this case, silver nanoparticles capped with an extract from dead honey bees — so they can patent the end result and turn it into a viable drug. And we further see that colon cancer cells are indeed susceptible to the silver treatment.

A Eighth Clinical Study

Another interesting clinical study, titled “In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells,” was published in the journal Biological Trace Element Research in March 2016.

In this study, researchers tested both gold and silver nanoparticles against HCT-116 colon cancer cells, and found that both types of nanoparticles demonstrated “reduced cell viability and increased cytotoxicity at concentrations of 200 ppm and 100 ppm respectively.”

In other words, colon cancer cells began to die when exposed to gold nanoparticles at 200 ppm and silver nanoparticles at 100 ppm.

The researchers concluded “Overall, these findings have proved that the synthesized gold and silver nanoparticles could be potent anti-colon cancer drugs.”

A Ninth Clinical Study

In another clinical study, this one titled “Cytotoxic Potential and Molecular Pathway Analysis of Silver Nanoparticles in Human Colon Cancer Cells HCT116” and published in the International Journal of Molecular Sciences in August 2018, researchers confirmed that relatively low concentrations of silver nanoparticles caused colon cancer cells to die.

The researchers wrote:

“Cytotoxicity assays indicated that the AgNPs in HCT116 colorectal cancer cells were very effective at low concentrations. The viability and proliferation of colon cancer cells treated with 5 µg/mL biogenic AgNPs were reduced by 50%.”

In other words, silver nanoparticles (i.e., AgNPs) used against colon cancer cells in a concentration of only 5 ppm reduced the viability of the cancer cells by 50%.

The researchers further wrote:

“Thus, the AgNP tumor suppressive effects were mediated by cell apoptosis following DNA damage, as well as by mitochondrial dysfunction and cell-cycle arrest following aberrant regulation of p53 effector proteins.”

Stated in plain English, the silver nanoparticles worked by causing the colon cancer cells to commit cellular suicide (i.e., apoptosis).

The apoptosis was caused when the silver nanoparticles came into contact with the colon cancer cells, damaged their DNA and caused the energy-producing portion of the cells (mitochondria) to malfunction, ultimately resulting in cell death.

The researchers summed up their study by stating:

“The human HCT116 cell line was exposed to 2–10 μg/mL AgNPs (6 nm) for 24 h followed by various cellular assays and RNA-Seq analysis.

To determine the potential anti-cancer effect of AgNPs, we synthesized AgNPs using naringenin, which is a flavonoid predominantly found in grapefruit.

HCT116 cells exposed to AgNPs for 24 h exhibited significant loss of cell viability and proliferation in a dose-dependent manner.

The 50% inhibitory concentrations of 5 µg/mL AgNPs remarkably increased LDH leakage, ROS generation, and MDA levels, and decreased dead-cell protease activity levels and ATP generation.

These events led to cell death by impairing mitochondrial function and by inducing DNA damage.”

Put another way, silver nanoparticles were synthesized using a grapefruit extract known as naringenin (making it easy for researchers to patent the product as a “drug,” because of the novel method of manufacturing the silver nanoparticles).

And when the colon cancer cells were exposed to concentrations of these silver nanoparticles between 2 ppm to 10 ppm in concentration, the DNA of the cancer cells was damaged (resulting in lower cancer cell proliferation), and the mitochondrial function of the cancer cells was impaired.

What’s more, at 5 ppm concentration of silver nanoparticles, 50% inhibition of the colon cancer cells was achieved — all of this in 24 hours!

A 10th Clinical Study

In a clinical study titled “Antitumor Activity of Silver Nanoparticles and Alpha-Lipoic Acid Combinations in Colorectal Cancer Induced Experimentally,” published in April 2018 in the journal Pharmacophore, researchers chemically-induced colorectal colon cancer tumors in 40 adult male albino wister rats, and had 10 more non-cancerous rats as controls.

They then divided the rats up into five groups:

  1. negative control (non-cancerous rats)
  2. positive control (cancer-induced rats)
  3. cancer-induced rats treated daily with 0.5 mg/ml silver nanoparticles orally for two weeks after cancer induction
  4. cancer-induced rats treated daily with Alpha-Lipoic Acid (60 mg/kg of body weight) for 2 weeks after colon cancer induction. Alpha-Lipoic Acid
  5. cancer-induced rats treated for two weeks after cancer induction with a combination of silver nanoparticles and Alpha-Lipoic Acid

After the two-week period was up, the rats were killed and their blood samples studied for cancer markers.

The researchers found that groups of rats treated with silver nanoparticles, Alpha-Lipoic Acid and a combination of silver nanoparticles and Alpha-Lipoic Acid all demonstrated significant amelioration (reduction) of biological markers of the chemically-induced cancer, compared to the negative and positive control groups.

The researchers stated:

“On administering silver nanoparticles, alpha lipoic acid and their combination, colon cancer biomarkers CEA and CCSA4 levels steadily returned to near normal.

CRC rats were treated with silver nanoparticles, alpha lipoic acid and their combination showed a significant reduction in TNF α, TGF β and CRP.

The silver nanoparticles had a pronounced effect on inhibited pro inflammatory cytokine.

… The present study revealed significant upregulation in the gene expression level of K-RAS in colon tissue of colorectal cancer induced rats.

…Treatment with silver nanoparticles in colorectal cancer induced rats led to significant reduction in KRAS gene expression level in colon tissue as shown in the current data.

The suggested mechanism for the inhibition of k-RAS gene expression level due to treatment with silver nanoparticles in colon cancer-induced rats is the ability of silver nanoparticles to suppress the activation of Akt and Erk.”

In plain English, the major cancer markers all diminished when the cancer-induced rats were treated with silver nanoparticles, Alpha-Lipoic Acid, or a combination of the two.

The researchers concluded:

“Based on our results, it could be concluded that silver nanoparticles plus ALA has a promising therapeutic role against colorectal cancer induced by 1,2 dimethylhydrazine as indicated by the observed improvement in the measured histological, molecular and biochemical markers.

These effects achieved through the powerful anti-inflammatory properties [of silver nanoparticles and of Alpha-Lipoic Acid]. These results represented good therapeutic approaches for intervention against progressive of colorectal cancer with special reference to the inflammatory response.”

Once again we see that colon cancer — this time colon cancer tumors induced in rats, rather than colon cancer cell lines in a test tube — is susceptible to silver nanoparticles.

An 11th Clinical Study

In another study, titled “Thermal Co-Reduction Engineered Silver Nanoparticles Induce Oxidative Cell Damage In Human Colon Cancer Cells Through Inhibition Of Reduced Glutathione And Induction Of Mitochondria-Involved Apoptosis,” published in November 2018 in the journal Chemico-Biological Interactions, the researchers wrote:

In this study, we report the detailed toxicological analysis of AgNPs fabricated by thermal co-reduction approach [i.e., another “novel” way of manufacturing silver nanoparticles so they can be patented as “drugs” — ED]  in human colon cancer cell line (HCT 116).”

The researchers go on to state that:

“It was also observed that AgNP induces oxidative stress on HCT116 by increased levels of lipid peroxidation and reduced levels of glutathione.”

In other words, like the other studies above, the silver nanoparticles were found to induce higher levels of reactive oxygen species upon contact with cancerous cells, resulting in damage to the unhealthy cells. The researchers further state:

“Mitochondrial membrane depolarization was also analysed and Western blot analysis confirms the increased level of Bcl and Caspase-3 which indicates the mitochondrial-mediated apoptosis. Additionally, flow cytometric analysis suggests cell cycle arrest in G2/M phase.”

In plain English, like the other studies, this study demonstrated that silver causes the cancer cells to kill themselves through the process called apoptosis.

Yes, a 12th Clinical Study

Yet another clinical study was published in April 2017 in the journal Artificial Cells, Nanomedicine, and Biotechnology. It was titled “Green Synthesis of Silver Nanoparticles Using Anthemis Atropatana Extract: Characterization and In Vitro Biological Activities.”

According to the researchers:

[Previous] studies have indicated good potential of AgNPs as anticancer and antibacterial agent. AgNPs destroy the mitochondrial respiration chain in cancer cells as well as degrading DNA, which ultimately results in cancer cells death. 

“This study aim to synthesize silver nanoparticles (AgNPs) using Anthemis atropatana extract and to evaluate their chemical characteristics and antimicrobial and cytotoxic effects. 

…In biological tests, the MTT results indicate the dose dependence of cytotoxic effects of AgNPs on colon cancer cell lines (HT29).

The AgNPs had maximum cytotoxicity on HT29 cancer cell line at 100 μg/ml concentration, which were statistically significant comparing control cells (p < .001).

Moreover, real time PCR and flow cytometry results confirmed the apoptotic effects of AgNPs.

According to the results, it seems that the green synthesis of AgNPs is an eco-friendly and cost effective approach. This research provides insight into the development of new anticancer and antibacterial agents.”

In a nutshell, silver nanoparticles synthesized using a plant extract native to Iran were tested against colon cancer cell line HT29, and were found to be most toxic to the cancer cells at 100 ppm.

The following chart from the study shows the control cancer cells (i.e., no treatment) on the far right. At 3.25 ppm silver nanoparticles, there was a more than 20% reduction in cancer cell survival. At 6.25 ppm silver nanoparticles, there was nearly a 50% reduction. At 12.5 ppm silver nanoparticles there was a near 60% reduction. At 25 ppm there was a near 80% reduction. At 50 ppm there was a near 90% reduction. And at 100 ppm there was close to 95% reduction in cancer cell survival.

The researchers concluded:

“In this study, A. atropatana extract was used for the first time as a reducing and capping agent to synthesize AgNPs without production of any harmful chemicals.

… the AgNPs had antibacterial and anticancer effects and it can induce the apoptosis more intensely than necrosis [i.e., death from cell injury — ED] in cancer cell line.

According to significant biological effects of the synthesized AgNPs, it suggested that further studies were performed for AgNPs pharmaceutical importance.”

In short, silver nanoparticles were demonstrated to be both antibacterial and have anti-cancer effects against the colon cancer cell line tested.

More Studies

At the time of this writing, there are probably close to a dozen more studies demonstrating that silver nanoparticles are effective cytotoxic agents against colon cancer.

There may even be more than that available. Indeed, the more I looked, online, the more I continued to find. But for the sake of brevity, I chose to limit this discussion to the 12 studies summarized above.

It’s important to note that with the exception of the rat study (see study #10 above) these studies are all in vitro studies (i.e., lab “test tube” studies). This means there’s a decided lack of animal and human studies. All that’s been proven so far, essentially, is that in the lab silver nanoparticles kill colon cancer cells quite handily.

That, of course, is a far cry from claiming that silver nanoparticles are an effective cancer treatment in humans or animals.

But these preliminary “test tube” studies — whose number continues to grow — should at some point in time spur researchers to do further animal studies, followed by human studies.

Until then, we won’t know what an appropriate dosage of silver would be, in terms of treating colon cancer in humans with colloidal silver or any other form of silver. Nor do we know what the proper method of administration should be for maximum effectiveness. So I, for one, look forward to more studies to come.

It’s quite exciting to see that researchers from around the world are looking into the anti-cancer effects of silver nanoparticles against colon cancer — one of the most deadly of all cancers.

And because these studies add to the plethora of studies demonstrating silver to be effective against numerous forms of cancer (50 of which studies are documented in my 126 page book, Colloidal Silver and Cancer: a Surprising Look), it all points to an exciting future in which silver might become one of the safest and most effective cancer treatments the world has ever known.

C:\Users\Barwick\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content.Word\44373021_s.jpgImportant Addendum: Where to Find Colloidal Silver

If you’re brand new to colloidal silver usage and are wondering where to buy it, it’s important to know that you can find it in just about any well-stocked health food store in America.  It’s also available on Amazon and numerous other websites.

But it can be extremely expensive. In fact, because colloidal silver works so well against numerous forms of infection and disease, it has the highest price mark-up of any nutritional supplement in existence.

The amount of actual silver in a four-ounce bottle of colloidal silver is about five to 12 cents worth.  (Yes, I said five to twelve cents.)

Yet because that small amount of silver is all it takes to decimate so many different kinds of infections, the manufacturers mark it up about 16,000%, charging a whopping $20 or $30 per bottle.

What’s more, manufacturers promoting the latest faddish colloidal silver product often charge far more per bottle – sometimes $35 to $50 for a tiny four-ounce bottle.

And people are more than willing to pay through the nose for these commercial colloidal silver products at health food stores because colloidal silver does indeed heal infections and prevent the spread of germs and disease faster and better than any other natural supplement on the planet!

So, commercially speaking, the retail price of colloidal silver at health food stores reflects its value to the consumer far more so than its true cost to produce. But here’s the good news:


Make Your Own High-Quality
Colloidal Silver for Pennies!

As I mentioned, typical health food store prices for colloidal silver can range from $20 to $30 for a tiny, four-ounce bottle.

But with a brand new Micro-Particle Colloidal Silver Generator from The Silver Edge, you can make your own safe, pure, high-quality micro-particle colloidal silver for about 36 cents a quart!  In other words, you can make it at actual cost, just like the big colloidal silver bottlers do.

Compared to typical health food store prices, your first two one-quart batches literally pay for the entire cost of your new generator!  Do you know of any other health product that literally pays for itself the very first few times you use it? The savings are absolutely astonishing!

In fact, by making your own high-quality colloidal silver with a brand new Micro-Particle Colloidal Silver Generator from The Silver Edge, you’ll be as close to having FREE colloidal silver as you can get, and for the rest of your life!

You’ll never have to pay those exorbitant health food store prices again!

The new Micro-Particle Colloidal Silver Generator is now the world’s #1 best-selling colloidal silver generator. Here are just a few reasons why you should own one…

  • It pays for itself after your very first batch or two — your total cost to make your first one-quart batch is about 36 cents, compared to the $240 you’d pay at a health food store if you bought an equivalent amount (i.e., eight of those little 4-ounce bottles they normally sell for $30 apiece)!
  • Safe, simple to operate…No special skills needed…You just set the handy timer, plug it in, walk away, and three hours later you have a perfect batch of therapeutic quality micro-particle colloidal silver…every time!  Here’s a short pictorial demonstrating how astonishingly easy it is to use a new Micro-Particle Colloidal Silver Generator from The Silver Edge:

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  • Produces uncommonly small silver micro-particles as low as .8 nm. That’s a fraction of a single nanometer. Compare that to health food store colloidal silver which can contain silver particles as large as 200 nm to 1,000 nm (or even larger), and you’ll see why micro-particle colloidal silver is the very best there is!  Smaller particles mean your body can absorb and utilize up to 99% of the colloidal silver you take, compared to maybe 30% or 40% with many health food store brands!
  • Runs on standard household electricity, but uses less power than a tiny Christmas tree bulb – you won’t even see a blip on your electric bill!
  • Produces uniform, crystal clear batches every single time that store for months, or even years, without losing potency!
  • Cannot produce silver chloride or unsafe substances – you get pure, therapeutic-quality micro-particle colloidal silver every time!

Just read through some of the testimonials below to see for yourself how you’ll save literally thousands of dollars per year by making your own colloidal silver with your brand new Micro-Particle Colloidal Silver Generator from The Silver Edge!

Customer Testimonials

Here’s what one customer recently wrote to tell us:

“Owning a Micro-Particle Colloidal Silver Generator from The Silver Edge has given us the luxury of being able to use high-quality colloidal silver any time we need it.  And we never have to worry about the costs because it only costs a few pennies per quart to make!  It is without a doubt the single-best money-saving appliance in my entire house!

Best of all, the machine is very easy to use, and easy to store. I was concerned about ease-of-use, but my fears were unfounded. After I got mine and used it, I immediately bought one and sent it to my 83 year old mom, and she uses it regularly as well.

Now that I have a Micro-Particle Colloidal Silver Generator, I can use colloidal silver for everything — disinfecting the kitchen sinks, countertops, and the cutting board… spraying the toilet bowls, and the bathroom countertops and sinks… spraying it on my toothbrush to prevent bacterial growth…rinsing my mouth with it to prevent cavities and gum disease…you name it.

I even put it in the laundry rinse cycle when I do my linens, towels and kitchen rags, so I don’t have to wash them as frequently. It really keeps them fresh, and there’s never any mold or mildew anywhere in our house.

I also put some in the cat’s water bowl each day, and the dog’s too.  We use it in the bathtub for skin problems.  And of course we drink it when our tummies are queasy, or when we feel a cold or flu coming on.  We also gargle with it in order to get rid of sore throats, and sniff it up our noses to get rid of sinus problems.

My husband even sprays it on his hair in the mornings, and has completely eliminated his lifelong dandruff problem.  And he sprays a little bit in his eyes from time to time, and now has no more recurrent problems with sties.”

— K. Sullivan, NM

And here’s what another happy customer wrote to say about the tremendous savings she’s achieved by no longer having to purchase her colloidal silver through health food stores:

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“We make a quart of colloidal silver at least once a week with the Micro-Particle Colloidal Silver Generator from the Silver Edge. I finally sat down and figured out how much this machine has been saving us. By making our own colloidal silver we’ve saved $11,503.20 this year alone, compared to the cost of colloidal silver at our local health food store.

The cost for colloidal silver at our local health food store is $30 for a tiny four-ounce bottle. But with my Micro-Particle Colloidal Silver Generator, I can make eight times that amount (i.e., a full quart) for about 35 cents total cost.

If I were to purchase a quart of colloidal silver at the health food store, which would be eight of those tiny, four-ounce bottles, the cost would be a whopping $240 (i.e., 8 x $30 = $240) compared to the 35 cents I now spend to make a full quart!

Here’s the breakdown of our costs to make a full quart of colloidal silver with our Micro-Particle Colloidal Silver Generator: It costs us about a dollar for a gallon of steam-distilled water at Walmart. So a quart of the steam-distilled water costs about 25 cents. And I estimate we use maybe a nickel’s worth of electricity and maybe another nickel’s worth of silver from the silver rods for every one-quart batch of colloidal silver we make. So that’s 35 cents a quart, all told, for each quart of micro-particle colloidal silver we make!

And frankly, considering how long the .999 fine silver rods have lasted (over a year and a half, so far, for the most recent set), I think it’s probably even cheaper than that. But it’s the lifetime savings we’ve experienced that’s just mind-boggling to me.

For example, we’ve had our Micro-Particle Colloidal Silver unit for nearly five years now. And as I mentioned we make one quart per week, and we spend about 35 cents a week on making colloidal silver.

This means we save about $239.65 a week by not having to purchase a quart’s worth of colloidal silver at our local health food store.  So do the math: In just one month, the savings is $958.60…in one year, the savings is $11,503.20…and in five years we’ve saved approximately $57,516.00!

When you put pencil to paper and figure it out, it definitely takes you by surprise. You just think ‘No way. I must have multiplied that wrong.’

But it’s true. The savings is legitimately well over $11,000 a year over health food store prices for colloidal silver, if you make and use a quart of colloidal silver a week like we do!  And we reap that incredible savings from the very reasonable $250 investment we made in purchasing our Micro-Particle Colloidal Silver Generator.

In their advertising literature, The Silver Edge says the unit completely pays for itself after your first couple of one-quart batches. But really, that’s quite an understatement when you realize the true extent of your savings!

Of course, once you start making your own colloidal silver with a Micro-Particle Colloidal Silver Generator from The Silver Edge, you don’t really think about how much you’re saving compared to health food store prices, because it just becomes a normal part of your everyday life. But the savings is nevertheless astonishing when you reflect on it.

What’s especially nice is being able to produce a significantly higher-quality colloidal silver than what’s generally available to the public through health food stores, especially at such a tiny, tiny fraction of the cost.”

— Marie Wilkey, SC

The Bottom Line…

With a high-quality Micro-Particle Colloidal Silver Generator from The Silver Edge, you’ll never again have to pay exorbitant health food store or internet vendor prices for high-quality colloidal silver!

Indeed, your first batch or two will indeed completely pay for the entire cost of your generator, compared to health food store prices!

What’s more, you’ll be able to give colloidal silver away FREE to family members, friends and neighbors, because you’ll be making it — literally — for only a few pennies per batch!

Simply click on this link to learn more about this phenomenal new breakthrough in colloidal silver-making technology, including our current, time-limited, money-saving offers that can save you up to $100 if you act quickly and decisively!

Meanwhile, I’ll be back next week with another insightful article on colloidal silver….

Yours for the safe, sane and responsible use of colloidal silver,


Steve Barwick, author

The Ultimate Colloidal Silver Manual

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Colloidal Silver Cures MRSA

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Meet Steve Barwick

Colloidal Silver

Important Note and Disclaimer: The contents of this Ezine have not been evaluated by the Food and Drug Administration. Information conveyed herein is from sources deemed to be accurate and reliable, but no guarantee can be made in regards to the accuracy and reliability thereof. The author, Steve Barwick, is a natural health journalist with over 30 years of experience writing professionally about natural health topics. He is not a doctor. Therefore, nothing stated in this Ezine should be construed as prescriptive in nature, nor is any part of this Ezine meant to be considered a substitute for professional medical advice. Nothing reported herein is intended to diagnose, treat, cure or prevent any disease. The author is simply reporting in journalistic fashion what he has learned during the past 17 years of journalistic research into colloidal silver and its usage. Therefore, the information and data presented should be considered for informational purposes only, and approached with caution. Readers should verify for themselves, and to their own satisfaction, from other knowledgeable sources such as their doctor, the accuracy and reliability of all reports, ideas, conclusions, comments and opinions stated herein. All important health care decisions should be made under the guidance and direction of a legitimate, knowledgeable and experienced health care professional. Readers are solely responsible for their choices. The author and publisher disclaim responsibility and/or liability for any loss or hardship that may be incurred as a result of the use or application of any information included in this Ezine.

Copyright 2019 | Life & Health Research Group, LLC | PO Box 1239 | Peoria AZ 85380-1239 | All rights reserved.


Click the image above to learn more about the Micro-Particle Colloidal Silver Generator that allows you to make high-quality colloidal silver for less than 36 cents a quart, and is so easy to use, even my 88 year old mom uses one!

P.O. Box 84910
Phoenix, AZ 85071

Phone Orders/Customer Service: 1-888-528-0559 (M-F, 8am to 4pm AZ time)
FAX Orders: (602) 943-2363 (24 hours a day)
Tech Support: (760) 253-2988 (M-F 9am to 5pm CA time)

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[IMPORTANT NOTE AND DISCLAIMER: We are not doctors. We are distributors of electronic appliances and nutritional supplements. Therefore we cannot and do not offer medical advice. Please do not call with medical questions. If you have a medical problem, please see your licensed physician. Self-treatment is not recommended. The FDA has not evaluated the information contained on this web site. Products distributed by The Silver Edge are not intended to diagnose, treat, cure or prevent any disease. Testimonials are the subjective experiences of our customers and are not intended to be construed as being prescriptive in nature, nor a guarantee that the usage methods described are safe, effective or reliable, nor a guarantee that your results will be the same; individual results may vary. Additionally, the contents of this web site are strictly for information purposes only, and should not in any way be construed as providing or attempting to provide medical advice. Information on this web site is derived from sources deemed to be accurate and reliable, but no guarantee, express or implied, can be made regarding the accuracy or reliability of same. Therefore readers are encouraged to verify for themselves and to their own satisfaction the accuracy and reliability of all reports, recommendations, conclusions, comments, and opinions. The Silver Edge does not make any claims or promises as to health benefits accruing from the use of any product. There is plenty of publicly available independent documentation -- both pro and con -- regarding the uses and efficacy of colloidal silver and its long history in health and medicine. For a comprehensive overview, you may want to obtain a copy of The Ultimate Colloidal Silver Manual (547 pages, from Life & Health Research Group, LLC, 1-888-846-9029). Or see the link above to "Some Interesting Sources of Information on Colloidal Silver." Colloidal silver generators are electronic appliances designed to produce high-quality silver colloid. They are not medical devices. The Silver Edge specifically disclaims responsibility or liability for any loss or hardship that may be incurred by the reader as a result of the application of any information included on this web site, or as a result of the use or misuse of any electronic product or nutritional supplement. You are solely responsible for your health and nutrition choices. Anyone with additional information on colloidal silver is encouraged to write to The Silver Edge at the address directly below, so that it can be shared with others who may be interested.]