Clinical Studies and Reports on the Antimicrobial Qualities of Colloidal Silver

The following PDF documents consist of a variety of clinical studies and independent research reports on the antimicrobial qualities of colloidal silver-related products including silver ions, silver compounds, silver nanoparticles, nanosilver compounds, silver-impregnated and silver-coated products, and many other forms of silver being used in a wide variety of ways, but almost all for the purpose of benefitting from the powerful antimicrobial qualities of silver itself.

These studies and reports are supplied for informational purposes only, and should not be construed in any way as providing medical advice or guidance. They cover a wide range of data on silver, including some surprising findings and discoveries regarding silver’s powerful antimicrobial, infection-fighting and disinfectant qualities.

These studies and reports are compiled here with the intent of giving the reader or researcher a general understanding of the many uses of antimicrobial silver, from a variety of viewpoints, both clinical and personal. The studies are not meant to convey efficacy of any particular colloidal silver product.

Because research into antimicrobial silver is ongoing, and because opinions and conclusions tend to vary depending upon the factors involved in different studies, these studies and reports should be considered merely as a starting point for your own research, and not be considered the final word on silver and its many antimicrobial, infection-fighting or disinfectant benefits.

Note to Publishers and Authors: If you feel any of these PDF files are on this site in violation of copyright, please inform me immediately by email, at, or at the phone number at the bottom of this page. These PDF files have been garnered from a variety of internet sources where they were found posted with no restrictions. They are here under fair use, and for non-commercial informational purposes only.

Anti-Inflammatory Effect Of Topical Nanocrystalline Silver Cream On Allergic Contact Dermatitis In A Guinea Pig Model

This clinical study, published in May 2004 in the journal of Clinical and Experimental Dermatology, demonstrated that a topical nanosilver cream was used to heal allergic contact dermatitis induced in guinea pigs via application of a chemical organic compound called dinitrochlorobenzene. Essentially, the researchers used a chemical organic compound to cause dermatitis on the guinea pigs.

Anti-Leishmanial Effect of Silver Nanoparticles and their Enhanced Anti-Parastic Activity Under UV Light

According to this clinical study, published in the International Journal of Nanomedicine in November 2011, researchers found for the first time that silver nanoparticles are effective against the Leishmaniasis pathogen — a protozoan parasite that causes Leishmaniasis, a disease that is potentially fatal if left untreated, and which causes ulcers of the skin, mouth and nose, plus fever, anemia and enlarged spleen and liver.

Anti-leukemia Activity of PVP-coated Silver Nanoparticles via Generation of Reactive Oxygen Species and Release of Silver Ions

This clinical study, published in the journal Biomaterials in October 2013, was specifically designed to determine whether or not exposure to silver nanoparticles would “inhibit the grown of acute myeloid leukemia (AML) cells,” and thus represent a viable potential treatment for leukemia (i.e., cancer of the blood and bone marrow). According to the study authors, “We found that silver nanoparticles could inhibit the viability of AML cells including isolates from AML patients.”

Anti-proliferative activity of silver nanoparticles

In this clinical study, published in the journal BMC Cell Biology in September 2009, researchers discovered that when human glioblastoma cells (malignant brain cancer cells) were exposed to silver nanoparticles, the cancer cells engulfed the silver particles (via endocytosis) resulting in chromosomal instability and mitotic arrest (i.e., the cancer cells can no longer divide efficiently in order to form new cancer cells).

Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coli

Electrically generated silver ions used in washing machines are shown to cause significant reductions in bacterial counts of Staph aureus and E. coli.

Antibacterial Activity and Mechanism of Silver Nanoparticles on Escherichia coli

In this clinical study conducted at the Guangdong Institute of Microbiology at Guangzhou, China, and published in 2010 in Applied Microbiology and Biotechnology, the researchers studied the antibacterial activity of silver nanoparticles against E. coli, as well as the mechanism through which silver nanoparticles provided inhibitory and bactericidal effects.

Antibacterial Activity of Silver-killed Bacteria: the “Zombies” Effect

Most researchers agree that silver kills bacteria in a three-fold manner, i.e., catalytic oxidation, cell wall disruption and penetration leading to disabling of the bacterium’s respiration and energy transfer systems, and prevention of replication by attaching to the DNA of the pathogen. What happens afterwards is what researchers did not know until now.

Antibacterial and Anticancer Activity of Silver Nanoparticles Synthesized from Cynodon dactylon Leaf Extract

In this clinical study, published in the Journal of Academia and Industrial Research (JAIR) in May 2015, researchers synthesized silver nanoparticles using Cynodon dactylon leaf extract, and then tested it against the HEpG-2 line of liver cancer cells, as well as against pathogenic microbes such as against Escherichia coli, Staphylococcus aureus, Micrococcus lutues and Salmonella typhimurium.

Antibacterial Efficacy of Colloidal Silver Alone and in Combination With Other Antibiotics on Isolates from Wound Infections

Low dose colloidal silver kills antibiotic-resistant staph and E.coli, and does not interfere with therapeutic efficacy of prescription antibiotics tested.

Antibacterial Efficacy Studies of Silver Nanoparticles Against Escherichia coli ATCC-15224

Silver nanoparticles are shown to dramatically reduce E. coli bacterial counts.

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[IMPORTANT NOTE AND DISCLAIMER: We are not doctors. We are distributors of electronic appliances and nutritional supplements. Therefore we cannot and do not offer medical advice. Please do not call with medical questions. If you have a medical problem, please see your licensed physician. Self-treatment is not recommended. The FDA has not evaluated the information contained on this web site. Products distributed by The Silver Edge are not intended to diagnose, treat, cure or prevent any disease. Testimonials are the subjective experiences of our customers and are not intended to be construed as being prescriptive in nature, nor a guarantee that the usage methods described are safe, effective or reliable, nor a guarantee that your results will be the same; individual results may vary. Additionally, the contents of this web site are strictly for information purposes only, and should not in any way be construed as providing or attempting to provide medical advice. Information on this web site is derived from sources deemed to be accurate and reliable, but no guarantee, express or implied, can be made regarding the accuracy or reliability of same. Therefore readers are encouraged to verify for themselves and to their own satisfaction the accuracy and reliability of all reports, recommendations, conclusions, comments, and opinions. The Silver Edge does not make any claims or promises as to health benefits accruing from the use of any product. There is plenty of publicly available independent documentation -- both pro and con -- regarding the uses and efficacy of colloidal silver and its long history in health and medicine. For a comprehensive overview, you may want to obtain a copy of The Ultimate Colloidal Silver Manual (547 pages, from Life & Health Research Group, LLC, 1-888-846-9029). Or see the link above to "Some Interesting Sources of Information on Colloidal Silver." Colloidal silver generators are electronic appliances designed to produce high-quality silver colloid. They are not medical devices. The Silver Edge specifically disclaims responsibility or liability for any loss or hardship that may be incurred by the reader as a result of the application of any information included on this web site, or as a result of the use or misuse of any electronic product or nutritional supplement. You are solely responsible for your health and nutrition choices. Anyone with additional information on colloidal silver is encouraged to write to The Silver Edge at the address directly below, so that it can be shared with others who may be interested.]